Pre-implantation Genetic Testing

The diagnostic procedures such as preimplantation genetic testing-Aneuploidy (PGT-A) for numerical chromosome abnormalities and PGT-M (testing embryos for disease causing mutations) enable a detailed investigation of the chromosome content of human gametes and embryos towards a healthy birth outcome.

PGT-A

A genetic test designed to select chromosomally normal embryos prior to their transfer to increase the chance of IVF success.

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PGT-M

A genetic test designed to select a disease free embryo to reduce the risk of having a child with an inherited condition.

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PGT-SR

A genetic test designed to detect inherited chromosome structural rearrangements and increase the chance of a successful pregnancy.

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Talk to your fertility specialist regarding the best PGT plan or plans for you.



Step by Step Workflow


Few cells from the outer layer of the embryo (that would form the placenta) are removed (biopsied) from the embryo and sent to RGCS for genetic analysis. Embryos will remain frozen on-site at the patient’s IVF center and in case of a normal genetic result an elective single embryo is transferred to the uterus.


Why add Preimplantation Genetic Testing in your IVF cycle?


One of the main causes of the relatively low reproductive success rates seen in humans is numerical chromosome abnormalities (aneuploidy) in the embryo. Aneuploidies are rarely compatible with life or can cause congenital diseases. PGT-A procedure would facilitate elective single-embryo transfer (eSET). PGT-A is NOT only designed for women of advanced maternal age - while it is true that an increase in age results in increased risk for aneuploidy, it is also true that younger women are also at risk aneuploid embryos in their IVF cycles.

Advantages include:

  • Analyses all autosomal and sex chromosomes abnormalities
  • Allows diagnosis of the most common chromosomal defects, including: Downs, Edwards, Patau, Turner, and Klinefelter’s syndrome, before it is returned to uterus
  • Increases the embryo implantation rate
  • Reduces the risk of miscarriage
  • Increases the efficiency of single embryo transfer by reducing the number of multiple pregnancies